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Drug, Gene and Protein Delivery
Therapeutic drugs, genes, peptides and other bioactive molecules can be delivered to target cells and organs for the treatments of diseases such as cancers, diabetes and asthma and for responding to specific biological stimuli.
Pulmonary delivery of drug, gene and protein in nanocarrier systems is one of our major areas of interest, since the action of drug entrapped in nanocarriers may exhibit prolonged residence time in the lung after inhalation, potentially reducing systemic side effects. Currently, our institute is developing nanocarrier systems for nasal delivery aiming to treat local nasal diseases (e.g. Sinusitis) and systemic diseases (e.g. Diabetes, hormone deficiencies, etc.). Synthesis, properties, computer modelling and applications of a range of functionalised nanocarriers such as dendrimers, liposomes, carbon nanotubes, cochleates, and niosomes are being investigated particularly in the area of aerosol delivery. Moreover, development of methods to manufacturing nanocarriers on a large scale are currently under investigation using vesicular nanosystems by applying various methods of size reduction, freeze-drying and spray-drying.
A significant volume of our research has focused on the development of nanosystems which are both stable and can be manufactured on a large scale.
The protein transduction domain of the HIV-1 transactivator of transcription, (Tat (48-60)), has been shown to transport P10, a cytotoxic peptide mimic of the cyclin dependent kinase inhibitor, p21WAF1/CIP1 into the nucleus of cancerous cells and induce apoptosis.
Single walled (SW) and multiwalled (MW) carbon nanotubes have attracted considerable interest for a wide range of applications in engineering, medicine, energy, construction and as components in composite materials for improving mechanical properties.
Nasal delivery is a useful delivery route in vaccination. The nose is the first point of contact with inhaled pathogens, rich in lymphoid tissue and has a relatively large surface area through which uptake of antigenic material can take place.
Dendrimers are highly branched macromolecules that have a well defined structure, allowing the precise control of size and shape, as well as terminal group functionality.